Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application

• Juliana P. L. Gonçalves,
• Afnan Q. Shaikh,
• Manuela Reitzig,
• Daria A. Kovalenko,
• Jan Michael,
• René Beutner,
• Gianaurelio Cuniberti,
• Dieter Scharnweber and
• Jörg Opitz

Beilstein J. Org. Chem. 2014, 10, 2765–2773, doi:10.3762/bjoc.10.293

• alloy surfaces and the nanodiamonds subsequently fixed by electrochemical immobilization. Titanium and its alloys have been widely used in bone and dental implants for being a metal that is biocompatible with body tissues and able to bind with adjacent bone during healing. In order to improve titanium

• substrate. Keywords: biofunctionalization; carbon-nanomaterials; detonation nanodiamond; electrochemical immobilization; surface modification; titanium alloy; Introduction Detonation nanodiamonds (DND) are a promising carbon-derived nanoscale material, which has been investigated since some decades due to

• . Sedimentation and agglomeration of several modified DND appeared to have a substantial influence on the success of the electrochemical immobilization. Silanized DND modified with O-phosphorylethanolamine 6 showed better dispersion in buffer compared to other samples and hence resulted in more homogeneous